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Research on Chinese medicine and premature ovarian insufficiency

Last updated: 3 June, 2018
by Steven Clavey, Traditional Chinese Gynaecology

A randomized, double-blind, placebo-controlled trial of Chinese herbal medicine capsules for the treatment of premature ovarian insufficiency.

Treatment with the Yangyin Shugan formula (YYSG) was more effective than placebo for improving menopausal symptoms, basal hormone levels, and ovarian function in women with premature ovarian insufficiency

From the journal Menopause (New York, N.Y.) [12 Mar 2018]

Authors: Cao XJ ,  Huang X ,  Liu J ,  Ma F ,  Zeng Y ,  Chen C ,  Wang JJ ,  Nie G ,  Wang XY

 

Abstract

This study was conducted to evaluate the treatment effectiveness of Chinese herbal medicine capsules containing the Yangyin Shugan formula (YYSG) in premature ovarian insufficiency (POI).

One-hundred forty-six women with POI participated in this stratified, randomized, double-blind, placebo-controlled clinical trial. 

Participants in two groups (n = 73 in each)–the YYSG group and control group–underwent treatment for 12 weeks. 

Outcome measures included the Chinese version Menopause-Specific Quality of Life questionnaire (CMS), serum levels of basal follicle-stimulating hormone (bFSH), basal estradiol, and anti-Mullerian hormone (AMH), the antral follicle count (AFC), and ovarian peak systolic velocity (PSV; cm/s).

Results

Treatment with YYSG significantly reduced the total scores of the Menopause-Specific Quality of Life questionnaire (CMS) at the end of the 12th week with statistical significance (P < 0.01); the vasomotor, psychosocial, physical, and sexual domains significantly improvement after treatment (P < 0.01). 

Compared with the baseline hormone levels, the Yangyin Shugan formula (YYSG) markedly decreased the bFSH level with statistical significance (P < 0.01) and improved the anti-Mullerian hormone (AMH) level (P < 0.01). 

Furthermore, YYSG greatly improved the participants’ antral follicle count (AFC) and ovarian PSV, compared with placebo (P < 0.01). 

There were no serious adverse events, and the safety indices of whole blood counts, renal function, and liver function were within the normal range, both before and after treatment.

Treatment with the Yangyin Shugan formula (YYSG) was more effective than placebo for improving menopausal symptoms, basal hormone levels, and ovarian function in women with premature ovarian insufficiency in Guangdong, China.

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